Research

Overview

Dr. Dandawate's research interest involves understanding key signaling pathways in cancer cells and how targeting these pathways with natural or synthetic compounds as well as the repurposing of FDA-approved drugs will contribute to improved treatment for cancer patients. Many anticancer drugs have the problem of water solubility and metabolic instability and hence use of drug delivery systems especially cyclodextrin-based formulations to overcome these problems is one of his interests. Following are ongoing projects he is working on.

1. Studying the role of taste receptors in the colon and esophageal cancers.

2. Establishing the role of histone demethylase KDM3A in pancreatic cancer.

  • Role of Bitter taste receptor TAS2R38 in colorectal cancer, Department of Defense, PI
  • The role of KDM3A-STAT3 interaction in pancreatic cancer, American Gastroenterological Society Research Foundation, PI
  • Dandawate, P, Kaushik, G, Ghosh, C, Standing, D, Ali Sayed, A., A, Choudhury, S, Subramaniam, D, Manzardo, A, Banerjee, T, Santra, S, Ramamoorthy, P, Butler, M, Padhye, S., B, Baranda, J, Kasi, A, Sun, W, Tawfik, O, Coppola, D, Malafa, M, Umar, S, Soares, M., J, Saha, S, Weir, S., J, Dhar, A, Jensen, R., A, Thomas, S., M, Anant, S. 2019. Diphenylbutylpiperidine Antipsychotic Drugs Inhibit Prolactin Receptor Signaling to Reduce Growth of Pancreatic Ductal Adenocarcinoma in Mice.. Gastroenterology
  • Dandawate, P, Ghosh, C, Palaniyandi, K, Paul, S, Rawal, S, Pradhan, R, Sayed AAA, Choudhury, S, Standing, D, Subramaniam, D, Padhye, S., B, Gunewardena, S, Thomas, S., M, Neil, M., O, Tawfik, O, Welch, D., R, Jensen, R., A, Maliski, S, Weir, S, Iwakuma, T, Anant, S, Dhar, A. 2019. The Histone Demethylase KDM3A, Increased in Human Pancreatic Tumors, Regulates Expression of DCLK1 and Promotes Tumorigenesis in Mice.. Gastroenterology, 157 (6), 1646-1659.e11
  • Dandawate, P, Subramaniam, D, Panovich, P, Standing, D, Krishnamachary, B, Kaushik, G, Thomas, S., M, Dhar, A, Weir, S., J, Jensen, R., A, Anant, S. 2020. Cucurbitacin B and I inhibits colon cancer growth by targeting the Notch signaling pathway.. Scientific reports, 10 (1), 1290
  • Dandawate, P, Ahmed, K, Padhye, S, Ahmad, A, Biersack, B. 2020. Anticancer Active Heterocyclic Chalcones: Recent Developments.. Anti-cancer agents in medicinal chemistry
  • Dandawate, P., R, Subramaniam, D, Padhye, S., B, Anant, S. 2016. Bitter melon: a panacea for inflammation and cancer.. Chinese journal of natural medicines, 14 (2), 81-100
  • Ghaisas, M., M, Dandawate, P., R, Zawar, S., A, Ahire, Y., S, Gandhi, S., P. 2010. Antioxidant, antinociceptive and anti-inflammatory activities of atorvastatin and rosuvastatin in various experimental models.. Inflammopharmacology, 18 (4), 169-77
  • Dandawate, P., R, Subramaniam, D, Jensen, R., A, Anant, S. 2016. Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy.. Seminars in cancer biology, 40-41, 192-208